Populus nigra (Salicaceae) absolute rich in phenolic acids, phenylpropanoïds and flavonoids as a new potent tyrosinase inhibitor.
Identifieur interne : 001710 ( Main/Exploration ); précédent : 001709; suivant : 001711Populus nigra (Salicaceae) absolute rich in phenolic acids, phenylpropanoïds and flavonoids as a new potent tyrosinase inhibitor.
Auteurs : A. Maack [France] ; A. Pegard [France]Source :
- Fitoterapia [ 1873-6971 ] ; 2016.
Descripteurs français
- KwdFr :
- Agaricales (enzymologie), Animaux (MeSH), Extraits de plantes (pharmacologie), Flavonoïdes (composition chimique), Flavonoïdes (isolement et purification), Humains (MeSH), Hydroxybenzoates (composition chimique), Hydroxybenzoates (isolement et purification), Monophenol monooxygenase (antagonistes et inhibiteurs), Mélanines (MeSH), Mélanocytes (effets des médicaments et des substances chimiques), Mélanome expérimental (MeSH), Phénylpropionates (composition chimique), Phénylpropionates (isolement et purification), Pigmentation de la peau (effets des médicaments et des substances chimiques), Populus (composition chimique), Pyrones (pharmacologie), Souris (MeSH).
- MESH :
- antagonistes et inhibiteurs : Monophenol monooxygenase.
- composition chimique : Flavonoïdes, Hydroxybenzoates, Phénylpropionates, Populus.
- effets des médicaments et des substances chimiques : Mélanocytes, Pigmentation de la peau.
- enzymologie : Agaricales.
- isolement et purification : Flavonoïdes, Hydroxybenzoates, Phénylpropionates.
- pharmacologie : Extraits de plantes, Pyrones.
- Animaux, Humains, Mélanines, Mélanome expérimental, Souris.
English descriptors
- KwdEn :
- Agaricales (enzymology), Animals (MeSH), Flavonoids (chemistry), Flavonoids (isolation & purification), Humans (MeSH), Hydroxybenzoates (chemistry), Hydroxybenzoates (isolation & purification), Melanins (MeSH), Melanocytes (drug effects), Melanoma, Experimental (MeSH), Mice (MeSH), Monophenol Monooxygenase (antagonists & inhibitors), Phenylpropionates (chemistry), Phenylpropionates (isolation & purification), Plant Extracts (pharmacology), Populus (chemistry), Pyrones (pharmacology), Skin Pigmentation (drug effects).
- MESH :
- chemical , antagonists & inhibitors : Monophenol Monooxygenase.
- chemical , chemistry : Flavonoids, Hydroxybenzoates, Phenylpropionates.
- chemistry : Populus.
- drug effects : Melanocytes, Skin Pigmentation.
- enzymology : Agaricales.
- chemical , isolation & purification : Flavonoids, Hydroxybenzoates, Phenylpropionates.
- chemical , pharmacology : Plant Extracts, Pyrones.
- Animals, Humans, Melanins, Melanoma, Experimental, Mice.
Abstract
The purpose of this study was to evaluate the tyrosinase inhibitory capacity of Populus nigra buds absolute (PBA) and compare it to kojic acid (KA), controversial reference tyrosinase inhibitor. Populus nigra buds were extracted with hexane and ethanol to obtain PBA. The inhibitory effect of this absolute was first tested on the mushroom Agaricus bisporus tyrosinase. Then the depigmenting potential of PBA was tested on B16F10 murine melanocytes by assaying the activity of tyrosinase and melanin content. Consecutively, a microscopic analysis of intracellular melanin granules was performed. Finally, melanised reconstructed human epidermis (RHE) were used to assess the lightening potential activity of this PBA on human skin. Results show that PBA inhibits A. bisporus tyrosinase (IC50=77±8ppm) and inhibits melanocytes B16F10 tyrosinase (IC50=27±1ppm). PBA decreases intracellular melanin levels, with 50% loss at 39±9ppm. Finally, PBA at 1000ppm lightens RHE and decreases their melanin content of 20%. PBA is a strong inhibitor of tyrosinase and reduces melanogenesis in melanocytes B16F10. Thus, PBA has potential applications in skin-lightening cosmetics.
DOI: 10.1016/j.fitote.2016.04.001
PubMed: 27091790
Affiliations:
Links toward previous steps (curation, corpus...)
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Populus nigra buds were extracted with hexane and ethanol to obtain PBA. The inhibitory effect of this absolute was first tested on the mushroom Agaricus bisporus tyrosinase. Then the depigmenting potential of PBA was tested on B16F10 murine melanocytes by assaying the activity of tyrosinase and melanin content. Consecutively, a microscopic analysis of intracellular melanin granules was performed. Finally, melanised reconstructed human epidermis (RHE) were used to assess the lightening potential activity of this PBA on human skin. Results show that PBA inhibits A. bisporus tyrosinase (IC50=77±8ppm) and inhibits melanocytes B16F10 tyrosinase (IC50=27±1ppm). PBA decreases intracellular melanin levels, with 50% loss at 39±9ppm. Finally, PBA at 1000ppm lightens RHE and decreases their melanin content of 20%. PBA is a strong inhibitor of tyrosinase and reduces melanogenesis in melanocytes B16F10. Thus, PBA has potential applications in skin-lightening cosmetics. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27091790</PMID><DateCompleted><Year>2017</Year><Month>01</Month><Day>17</Day></DateCompleted><DateRevised><Year>2018</Year><Month>08</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-6971</ISSN><JournalIssue CitedMedium="Internet"><Volume>111</Volume><PubDate><Year>2016</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Fitoterapia</Title><ISOAbbreviation>Fitoterapia</ISOAbbreviation></Journal><ArticleTitle>Populus nigra (Salicaceae) absolute rich in phenolic acids, phenylpropanoïds and flavonoids as a new potent tyrosinase inhibitor.</ArticleTitle><Pagination><MedlinePgn>95-101</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.fitote.2016.04.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0367-326X(16)30064-8</ELocationID><Abstract><AbstractText>The purpose of this study was to evaluate the tyrosinase inhibitory capacity of Populus nigra buds absolute (PBA) and compare it to kojic acid (KA), controversial reference tyrosinase inhibitor. Populus nigra buds were extracted with hexane and ethanol to obtain PBA. The inhibitory effect of this absolute was first tested on the mushroom Agaricus bisporus tyrosinase. Then the depigmenting potential of PBA was tested on B16F10 murine melanocytes by assaying the activity of tyrosinase and melanin content. Consecutively, a microscopic analysis of intracellular melanin granules was performed. Finally, melanised reconstructed human epidermis (RHE) were used to assess the lightening potential activity of this PBA on human skin. Results show that PBA inhibits A. bisporus tyrosinase (IC50=77±8ppm) and inhibits melanocytes B16F10 tyrosinase (IC50=27±1ppm). PBA decreases intracellular melanin levels, with 50% loss at 39±9ppm. Finally, PBA at 1000ppm lightens RHE and decreases their melanin content of 20%. PBA is a strong inhibitor of tyrosinase and reduces melanogenesis in melanocytes B16F10. Thus, PBA has potential applications in skin-lightening cosmetics. </AbstractText><CopyrightInformation>Copyright © 2016. Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maack</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Aromacosmetic Laboratory, Robertet SA, 37 avenue Sidi Brahim, 06130 Grasse, France. Electronic address: ameliemaack@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pegard</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Aromacosmetic Laboratory, Robertet SA, 37 avenue Sidi Brahim, 06130 Grasse, France. 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MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D062385" MajorTopicYN="N">Hydroxybenzoates</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008543" MajorTopicYN="N">Melanins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008544" MajorTopicYN="N">Melanocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008546" MajorTopicYN="N">Melanoma, Experimental</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014442" MajorTopicYN="N">Monophenol Monooxygenase</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010666" MajorTopicYN="N">Phenylpropionates</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011753" MajorTopicYN="N">Pyrones</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012880" MajorTopicYN="N">Skin Pigmentation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">1,1-Diphenyl-2-picrylhydrazyl radical</Keyword><Keyword MajorTopicYN="N">1-(2,6-Dihydroxy-4-methoxyphenyl)-3-phenyl-2-propenone</Keyword><Keyword MajorTopicYN="N">B16F10 murine melanoma cells culture</Keyword><Keyword MajorTopicYN="N">Kojic acid</Keyword><Keyword MajorTopicYN="N">Melanogenesis</Keyword><Keyword MajorTopicYN="N">Pinocembrin</Keyword><Keyword MajorTopicYN="N">Populus nigra buds</Keyword><Keyword MajorTopicYN="N">Tyrosinase inhibition</Keyword><Keyword MajorTopicYN="N">Whitening cosmetic</Keyword><Keyword MajorTopicYN="N">l-DOPA</Keyword><Keyword MajorTopicYN="N">l-Tyrosine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>01</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>03</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>04</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27091790</ArticleId><ArticleId IdType="pii">S0367-326X(16)30064-8</ArticleId><ArticleId 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